Srinivas Koduru PhD

300 Alumni Dr, #306,

Lexington 40503 KY, USA

+1 859 576 8082

sreenivasvedic@gmail.com

Sreenivasvedic.googlepages.com

Date of birth: 7th June, 1977, Marital status: Married. Citizenship:  Indian

Qualifications

ü  Post Doctoral Scholar at Department of Clinical Sciences, University of Kentucky, Lexington, KY, USA (2008-Current).

ü  Post Doctoral fellow at Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, CA, USA (2007).

ü  Doctor of Philosophy (PhD) in Botany (Phytomedicine) from University of Fort Hare, Alice, South Africa. 2004-2006. Graduated on May 5th, 2007.

ü  M.Sc Biotechnology with first Class from Swami Ramanand Teerth Marathwada University (SRTMU), Nanded, Maharastra State, India. 2001-2003.

ü  B.Sc in Microbiology, Genetics and Chemistry with First Class from Osmania University, Hyderabad, Andhra Pradesh State, India. 1998-2001.

ü  Intermediate (10+2): Botany, Zoology, Physic and Chemistry from Board of Intermediate, Andhra Pradesh state, India. 1993-1995.

Computer Skills

ü  Post Graduate Diploma in Computer Application (2 years)

·     C, C++, HTML, Windows 95, 98, 2000, NT, XP and Vista.

·     MS Office 95, 2000, 2003 and 2007 (Word, Excel, Power Point and Access). Adobe Photoshop, Adobe elements.

·     Scientific statistical analysis using various software.

·     Excellent internet browsing skills.

 

Area of Interests

·     Molecular biology of cancer cells

·     Human genetics

·     Cancer biology

·     Cell signaling

·     Biological activity of phytochemicals (anti-cancer)

·     Microbiology and immunology

Research Projects


1.     Post Doctoral Scholar at University of Kentucky: Molecular mechanisms of Breast, Lung, Colon and Prostate Cancers which are including various signaling pathways, effect of natural compounds, study of in vitro and in vivo models (Cancer Biology).

2.    Post Doctoral Fellow at UCLA: Characterization of HSF4 gene with αB crystalline gene (Molecular Biology).


3.    PhD Thesis:  Validating the use of Solanum aculeastrum for the treatment of cancer in the Eastern Cape, South Africa. University of Fort Hare, South Africa (2004-2006). Supervisor: Prof. AJ Afolayan; Co-supervisor: Prof. DS Grierson. 


4.   Research Training in Human Cell Culture techniques and Anticancer Screening at Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa (Funded by National Research Foundation, South Africa).


5.    Research Project: Association of Genetic and Biochemical markers with the Primary Myopia, Department of Genetics, Osmania University, Hyderabad, India.


6.   MSc Thesis (Dissertation & Research Methodology): Extraction and characterization of L-Asparaginase from Proteus vulgaris: Department of Biotechnology, S.R.T.M University, Nanded, India.

Technical Editor for following Journals

1.     International Journal of Cancer Research

2.    Pakistan Journal of Biological Sciences

3.    Journal of Pharmacology and Toxicology

4.   International Journal of Pharmacology

5.    American Journal of Plant Physiology

6.   Asian Journal of Cell Biology

7.    International Journal of Biological Chemistry

8.   Research Journal of Immunology

9.   Asian Journal of Biotechnology

10.     Journal of Biological Sciences

Reviewer for following Journals

1.       Journal of Medicinal Plants Research

2.      Egyptian Journal of Biochemistry and Molecular Biology

3.      Pharmaceutical Biology

4.     Tropical Journal of Pharmaceutical Research

5.      Journal of Cell and Animal Biology

6.     Pakistan Journal of Biological Sciences

7.      Journal of Biological Sciences

8.     American Journal of Plant Physiology

9.     International Journal of Pharmacology

10.        Journal of Pharmacology and Toxicology

11.          International Journal of Cancer Research

12.         Biotechnology

Honors/Awards

1.     Travel Award for poster presentation at the Society for Basic Urologic Research (SBUR) Annual Meeting, 2008 at Phoenix, Arizona, USA: 20th to 23rd November, 2008.

2.    Post Doctoral Fellowship, 2008-09 - College of Health Sciences, University of Kentucky, KY, USA.

3.    Post Doctoral Fellowship, 2007 - David Geffen School of Medicine at UCLA, Jules Stein Eye institute, Los Angeles, CA, USA.

4.   Travel and Training grant, Feb-2006 - National Research Foundation, South Africa.

5.    PhD Fellowship, 2004-2006 - National Research Foundation, South Africa.

Invited Seminars/Presentations

1.       Clinical & Reproductive Sciences Seminar Series: FOXO 3a regulates Par-4 activation and induces apoptosis in AIPC cells. 23rd Oct, 2008.

Teaching experience

1.     Department of Botany, University of Fort Hare, South Africa (Feb 2005- Nov 2006).

2.    Department of Biochemistry and Microbiology, University of Fort Hare, South Africa (Jan-Dec, 2004).

Professional Membership

1.     Associate Member - American Association for Cancer Research (AACR): 2007-Current.

2.    Associate Member - American Society of Clinical Oncology (ACSO): 2008-Current.

3.    Active Member - The European Association for Cancer Research (EACR): 2008-Current.

4.   Associate Member - Sigma Xi, the Scientific Research Society: 2008-Current.

5.    In-Training Member - The Society for Basic Urologic Research (SBUR): 2008-Current.

6.   Post Doctoral Fellow Membership - Canadian Society of Biochemistry, Molecular & Cellular Biology (CSBMCB): 2008-Current.

7.    Member - South African Association of Botany (SAAB): 2005-2006.

8.   Member-Indigenous Plant Use Forum (IPUF): 2004-2006.

Conference attended with title of Oral & Poster Presentations

1.     Srinivas Koduru, Raj Kumar, S Srinivasan, Damodaran Chendil. Activation of FOXO3a regulates the pro-apoptotic gene Par-4 and induces apoptosis in the androgen independent prostate cancer cells: Received a Travel award (Presented at the annual meeting of Society for Basic Urologic Research, Phoenix, Arizona, USA, 2008).

2.    Raj Kumar, Srinivas Koduru, S Srinivasan, Damodaran Chendil. Inhibition of PI3K medicated Akt signaling in Androgen independent prostate cancer by a dietary compound Psoralidin (Presented at the annual meeting of Society for Basic Urologic Research, Phoenix, Arizona, USA, 2008).

3.    Srinivas Koduru, Raj Kumar, S Srinivasan, Damodaran Chendil. FOXO 3A regulates Par-4 activation and induces apoptosis in AIPC cells (Presented at the Markey Cancer Research Day, University of Kentucky, Lexington, KY, USA, 2008).

4.   Raj Kumar, Srinivas Koduru, S Srinivasan, Damodaran Chendil. Markey Cancer Research Day, 2008: Psoralidin inhibits EGFR mediated pro-survival signaling in prostate cancer cells (Presented at the Markey Cancer Research Day, University of Kentucky, Lexington, KY, USA, 2008).

5.    S Srinivasan, Srinivas Koduru, Raj Kumar, Damodaran Chendil. Diosgenin targets Akt-mediated pro-survival signaling in human breast cancer cells (Presented at the Markey Cancer Research Day, University of Kentucky, Lexington, KY, USA, 2008).

6.   Srinivas Koduru, Raj Kumar, S Srinivasan, Damodaran Chendil. FOXO 3a induces apoptosis in AIPC cells by regulating the pro-apoptotic gene Par-4: Late-Breaking Poster (Presented at the 99th Annual Meeting of AACR, San Diego, CA, USA, 2008).

7.    S Srinivasan, Srinivas Koduru, Raj Kumar, Damodaran Chendil Diosgenin inhibits Akt-mediated signaling in breast cancer cells (Presented at the 99th Annual Meeting of AACR, San Diego, CA, USA, 2008).

8.   Raj Kumar, Srinivas Koduru, S Srinivasan, Damodaran Chendil. A dietary compound Psoralidin act as a potent “Akt inhibitor” in prostate cancer cells (Presented at the 99th Annual Meeting of AACR, San Diego, CA, USA, 2008).

9.   Srinivas Koduru, D Grierson, M Van de Venter, AJ Afolayan. Validating the anticancer properties of two compounds isolated from Solanum aculeastrum (26th Annual meeting of Indian Association for Cancer Research at Bhubaneswar, Orissa, India, 2007).

10.       Srinivas Koduru, D Grierson, M Van de Venter, AJ Afolayan. Validating the anticancer property of Solanum aculeastrum (Presented at the Annual meeting of South African Association of Botanists (SAAB), Port Elizabeth, South Africa, 2007).

11.        Srinivas Koduru, D Grierson, AJ Afolayan. Ethnobotanical information of plants used for the treatment of various cancers in the Eastern Cape Province, South Africa. (Presented at the Annual meeting of Indigenous Plant Use Forum (IPUF), Graham’s town, South Africa, 2006).

Peer-reviewed Publications/ Chapters in Books

1.       Srinivas Koduru, Raj Kumar, S Srinivasan, Damodaran Chendil, 2008. FOXO3A regulates Par-4 activation and induces apoptosis in AIPC cells. Oncogene: ready for submission.  

2.      Srinivas Koduru, S Srinivasan, R Kumar, J Rohr and Damodaran Chendil, 2008. Identification of a Potent Herbal Molecule for the treatment of Breast Cancer. BMC Cancer: Inpress.

3.      Srinivasan Sowmyalakshmi, Srinivas Koduru, Raj Kumar and Damodaran Chendil, 2008. Diosgenin Targets Akt-Mediated Pro-Survival Signaling in Human Breast Cancer Cells. International Journal of Cancer: In review.

4.     Raj Kumar, Sowmyalakshmi Srinivasan, Srinivas Koduru, Pallab Pahari, Jürgen Rohr,Natasha Kyprianou and Chendil Damodaran, 2008. Psoralidin, An Herbal Molecule Inhibits PI3K Mediated Akt Signaling in Androgen Independent Prostate Cancer (AIPC) Cells. Cancer Prevention Research: In press.

5.      Adedapo AA, FO Jimoh, Srinivas Koduru, AJ Afolayan, PJ Masika, 2008. Antibacterial and antioxidant properties of the methanol extracts of the leaves and stems of Calpurnia aurea. BMC Complementary and Alternative Medicine 8:53.

6.     Adedapo AA, Koduru S, Jimoh FO, Masika PJ and AJ Afolayan (2008). An Ethnoveterinary Survey and the Antibacterial Activity of Some Plants in the Eastern Cape Province of South Africa. 22:1-7. Recent Progress in Medicinal Plants, (eds) SK Sharma, JN Govil and VK Singh, Studium Press LLC, USA. ISBN: 1-9336991-2-4.

7.      Adedapo AA, FO Jimoh, S Koduru, PJ Masika, AJ Afolayan, 2008. Evaluation of the medicinal potentials of the methanol extracts of the leaves and stems of Halleria lucida. Bioresource Technology 99 (10): 4158-4163 (July 2008).

8.     Srinivas Koduru, DS Grierson, M van de Venter and AJ Afolayan, 2007. Anticancer activity and induction of apoptosis in tumour cell lines of steroid alkaloids from Solanum aculeastrum. Pharmaceutical Biology 45 (8): 613-618.

9.     Srinivas Koduru, DS Grierson and AJ Afolayan, 2007. Ethnobotanical information of plants used for the treatment of cancer in the Eastern Cape, South Africa. Current Science 92 (7): 906-908.

10.         Srinivas Koduru, FO Jimoh and AJ. Afolayan, 2007. Antioxidant activity of two steroid alkaloids extracted from the Solanum aculeastrum. Journal of Pharmacology and Toxicology 2 (2): 160-167.

11.          AJ Afolayan, FO Jimoh, MO Sofidiya, S Koduru and FB Lewu, 2007. Medicinal potential of the root of Arctotis arctotoides. Pharmaceutical Biology 45 (6): 486-493.

12.          Srinivas Koduru, DS Grierson and AJ Afolayan, 2006. Antimicrobial activity of Solanum aculeastrum. Pharmaceutical Biology 44 (4):283-86.

13.         Srinivas Koduru, DS Grierson, M van de Venter and AJ Afolayan, 2006. In vitro antitumour activity of Solanum aculeastrum berries on cultured three carcinoma cell lines. International Journal of Cancer Research 2 (4): 397-402.

14.         Srinivas Koduru, DS Grierson, MA Aderogba, JN Eloff and AJ Afolayan, 2006. Antioxidant activity of Solanum aculeastrum (Solanaceae) berries. International Journal of Pharmacology 2(2): 262-264.

15.         Srinivas Koduru, OT Asekun, DS Grierson and AJ Afolayan, 2006. Isolation of volatile compounds from the Solanum aculeastrum (Solanaceae). Journal of Essential Oils-Bearing Plants 9(1):65-69.

16.         Srinivas Koduru, DS Grierson and AJ Afolayan, 2006. The foliar micro-morphology of Solanum aculeastrum. Pakistan Journal of Biological Sciences 9(6): 1056-1060.

17.         Srinivas Koduru, DS Grierson and AJ Afolayan, 2006. Effect of high temperatures on seed germination of Solanum aculeastrum. Asian Journal of Plant Sciences 5(2): 353-356.

Greatly involved in:

1.      Search of Anticancer agents (Natural and dietary compounds), and study of intracellular signaling pathways in Prostate, Colon, Breast, Lung cancers cells as well as Xenograft and transgenic models (FOXO3a, Notch, PI3K/Akt, Par-4, mTOR, NF-kB, Bcl family, MAPK signaling pathways and cell cycle regulation).